abstract：BACKGROUND:Oligodendroglial tumors present us with some unsolved problems with reference to the pathological diagnosis of the malignancy, the classification, and the biological behavior. PATIENTS AND METHODS:We investigated 60 surgical specimens from 47 patients. This series contained 17 oligodendrogliomas, 4 oligo-as...

journal_title：Clinical neuropathology

authors： Saito A,Nakazato Y

更新日期：1999-03-01 00:00:00

abstract：:Primary leptomeningeal lymphomas are rare, and usually follow a rapid clinical course with early systemic involvement. A 60-year-old woman presented with a 3-year history of worsening seizures and memory loss. Neuroimaging showed widespread meningeal calcification. After extensive investigations a meningeal biopsy rev...

journal_title：Clinical neuropathology

authors： King A,Wilson H,Penney C,Michael W

更新日期：1998-11-01 00:00:00

abstract：:A new clinicopathological case of Devic's neuromyelitis optica, including unusual predominant clinical features (fatal dysautonomia) is described herein: pathological examination showed extensive and severe demyelination mainly involving the optic nerves, the medulla, and spinal cord, which was particularly pronounced...

journal_title：Clinical neuropathology

authors： Baudoin D,Gambarelli D,Gayraud D,Bensa P,Nicoli F,Sudan N,Gastaut JL,Viallet F

更新日期：1998-07-01 00:00:00

abstract：:In this study we present 2 postmenopausal women who showed clinical symptoms that resembled those of a rather well-defined group of vascular dementia disorders, termed subcortical dementia (Binswanger disease, CADASIL). Patient 1 exhibited mitochondrial DNA (mtDNA) variants in the ND5 gene at position 13,708 and the C...

journal_title：Clinical neuropathology

authors： Haferkamp O,Rosenau W,Scheuerle A,Pietrczyk C,Skowronek P,Rödel G

更新日期：1998-03-01 00:00:00

abstract：:Preparing for a retrospective study of senile degeneration in schizophrenia, we had occasion to explore the suitability of an old collection formalin-fixed brains and paraffin blocks for study by modern staining methods. Tissue that had been in formalin for 50 years was embedded in paraffin. Sections were then stained...

journal_title：Clinical neuropathology

authors： Dwork AJ,Liu D,Kaufman MA,Prohovnik I

更新日期：1998-01-01 00:00:00

abstract：:Traditional views of pure alexia have held that the disorder results from a disconnection between the secondary visual cortices of both hemispheres and the angular gyrus of the dominant hemisphere. Evidence has accumulated, however, suggesting the importance of the posterior inferior temporal area in visual language p...

journal_title：Clinical neuropathology

authors： Beversdorf DQ,Ratcliffe NR,Rhodes CH,Reeves AG

更新日期：1997-11-01 00:00:00

abstract：:A case of cerebellar lipomatous medulloblastoma in a 55-year-old male subject, clinically presenting with signs of intracranial hemorrhage and cerebellar dysfunction, is described. Magnetic resonance imaging revealed an enhancing irregular vermian lesion invading the left cerebellar hemisphere. The patient underwent a...

journal_title：Clinical neuropathology

authors： Orlandi A,Marino B,Brunori M,Greco R,Spagnoli LG

更新日期：1997-07-01 00:00:00

abstract：BACKGROUND:Adult polyglucosan body disease (APBD) is a rare disorder, presenting with varying combinations and severity of upper and lower motor neuron dysfunction, sensory deficits, dementia, and urinary incontinence. Onset is in the 40s or 50s. The diagnosis is made by finding polyglucosan bodies (PB) in histologic s...

journal_title：Clinical neuropathology

authors： Bigio EH,Weiner MF,Bonte FJ,White CL

更新日期：1997-07-01 00:00:00

abstract：:We report an autopsy case of preclinical primary central nervous system (CNS) lymphoma. The case was an 89-year-old female who died of rupture of a thoracic aortic aneurysm. No neurological abnormalities were found throughout our clinical observation. Serum anti-human T-cell leukemia virus type 1 and anti-human immuno...

journal_title：Clinical neuropathology

authors： Sawabe M,Esaki Y,Tsubokou Y,Takubo K,Yamada S,Mizutani T,Kanazawa A

更新日期：1997-03-01 00:00:00

abstract：:Bunina bodies, which are small eosinophilic intracytoplasmic inclusions, have been considered to be specific for amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease of unknown cause in adults. They are found usually in the remaining lower motor neurons. We encountered a 66-year-old woman with sporad...

journal_title：Clinical neuropathology

authors： Iwanaga K,Wakabayashi K,Honma Y,Takahashi H

更新日期：1997-01-01 00:00:00

abstract：:Recognition of apoptotic cells has recently been facilitated by in situ end-labeling (ISEL) techniques which identify DNA strand breaks. The ISEL assay has been applied in 26 brain tumors, meningiomas, and gliomas of different grade of malignancy in order to determine the apoptotic index (AI). Apoptotic cells were rea...

journal_title：Clinical neuropathology

authors： Patsouris E,Davaki P,Kapranos N,Davaris P,Papageorgiou K

更新日期：1996-11-01 00:00:00

abstract：:Lymphocytic adenohypophysitis can cause pituitary expansion and hypopituitarism closely mimicking the features of a pituitary adenoma. In contrast to pituitary adenoma, lymphocytic adenohypophysitis occurs almost exclusively in young women in relation to pregnancy. We report a case of a 43-year-old nonpregnant nullipa...

journal_title：Clinical neuropathology

authors： Hartmann I,Tallen G,Gräf KJ,Unterberg A,Lanksch WR,Stoltenburg-Didinger G

更新日期：1996-07-01 00:00:00

abstract：:We describe a 47-year-old patient with intracerebral tuberculoma of the falx cerebri and fronto-parietal cerebral cortex. The patient presented after a single episode of epileptic seizures. Computed tomography and MRI scans were suggestive of meningioma. At surgery a granulomatous tumor was removed that adhered to the...

journal_title：Clinical neuropathology

authors： Isenmann S,Zimmermann DR,Wichmann W,Moll C

更新日期：1996-05-01 00:00:00

abstract：:Axonal changes which develop around hematogenous metastases of the human brain were studied by immunohistochemistry using a monoclonal antibody to beta-amyloid precursor protein (beta APP) and the ABC method combined with glucose-glucose oxidase technique and nickel enhancement. The metastases were obtained from 18 au...

journal_title：Clinical neuropathology

authors： Zhang M,Olsson Y

更新日期：1996-03-01 00:00:00

abstract：:We describe a patient affected by chronic inflammatory demyelinating polyneuropathy (CIDP) whose sural nerve biopsy revealed a marked edema of the myelin sheath. Since this change has been previously described in human peripheral nerves only in CIDP patients, we suggest that intramyelinic edema may have a role in the ...

journal_title：Clinical neuropathology

authors： Sabatelli M,Mignogna T,Lippi G,Porcu C,Tonali P

更新日期：1996-01-01 00:00:00

abstract：:A 52-year-old woman developed progressive sensory polyneuropathy leading to death in 1.5 years. Electromyography and peripheral nerve biopsy had revealed severe axonal degeneration. Neuropathological examination showed involvement of all dorsal root ganglia with loss of the bipolar nerve cells, degeneration of the rem...

journal_title：Clinical neuropathology

authors： Reske-Nielsen E,Reintoft I,Bömers K

更新日期：1996-01-01 00:00:00

abstract：:Medulloblastomas may be difficult to recognize in late middle age and the elderly because of their rarity and their histological similarity, particularly in frozen sections, to common, poorly differentiated, metastatic tumors, notably the small cell carcinoma of lung. This report describes the occurrence of medullobla...

journal_title：Clinical neuropathology

authors： Ramsay DA,Bonnin J,MacDonald DR,Assis L

更新日期：1995-11-01 00:00:00

abstract：:Central nervous system (CNS) abnormalities attributed to direct effects of HIV infection are seen in most of children with acquired immunodeficiency syndrome (AIDS). Secondary CNS infections with opportunistic and common pathogens are infrequent in this age group. We report 9 cases of opportunistic infection of the CN...

journal_title：Clinical neuropathology

authors： Wrzolek MA,Brudkowska J,Kozlowski PB,Rao C,Anzil AP,Klein EA,Del Rosario C,Abdu A,Kaufman L,Chandler FW

更新日期：1995-07-01 00:00:00

abstract：:A rare case of motor neuron disease and involvement of the pallido-luysio-nigral system and brainstem tegmentum is presented. A 51-year-old man developed progressive muscle atrophy with fasciculation predominantly in the shoulder girdle, upper arms, upper back, and neck in addition to hyperreflexia and a positive Chad...

journal_title：Clinical neuropathology

authors： Kato S,Oda M,Murahashi M,Suda N

更新日期：1995-07-01 00:00:00

abstract：:Human glioblastomas were evaluated for overexpression of the epidermal growth factor receptor (EGFR) in a therapeutic trial with the anti-EGFR antibody EMD 55900. A total of 55 cases were examined by immunohistochemistry using 4 different monoclonal antibodies on frozen or on paraffin sections: EGFR-1 (Amersham), E 62...

journal_title：Clinical neuropathology

authors： Schober R,Bilzer T,Waha A,Reifenberger G,Wechsler W,von Deimling A,Wiestler OD,Westphal M,Kemshead JT,Vega F

更新日期：1995-05-01 00:00:00

abstract：:This immunohistochemical study compares the localization of the neuronal class III beta-tubulin isotype (beta III) to that of the proliferating cell nuclear antigen (PCNA)/cyclin in 46 cerebellar neuroblastic tumors (medulloblastomas). Both class III beta-tubulin (beta III) and PCNA/cyclin reactivities were present in...

journal_title：Clinical neuropathology

authors： Katsetos CD,Krishna L,Frankfurter A,Karkavelas G,Wolfe DE,Valsamis MP,Schiffer D,Vlachos IN,Urich H

更新日期：1995-03-01 00:00:00

abstract：:A 78-year-old man had extensive necrosis of the posterior lobe of the pituitary at autopsy. The anterior lobe was normal. This pattern of damage to the posterior lobe has not been described to date. ...

journal_title：Clinical neuropathology

authors： Mooney EE,Toner M,Farrell MA

更新日期：1995-01-01 00:00:00

abstract：:A case of solitary eosinophilic granuloma of the temporal lobe is reported and compared with seven previously documented cases. Long-term clinical follow-up information was obtained on two cases that were originally reported in 1977 and 1981. Solitary eosinophilic granuloma of the cerebral hemisphere, a rare manifesta...

journal_title：Clinical neuropathology

authors： Montine TJ,Hollensead SC,Ellis WG,Martin JS,Moffat EJ,Burger PC

更新日期：1994-07-01 00:00:00

abstract：:An infant with hypotonia and recurrent apneic spells died with a diagnosis of pyruvate dehydrogenase deficiency and showed typical pathological changes of Leigh's syndrome at postmortem. Despite the prominence of symptoms suggesting dysfunction of brainstem respiratory centers during life, lesions were not found in th...

journal_title：Clinical neuropathology

authors： Matthews PM,Nagy Z,Brown GK,Land J,Squier MV

更新日期：1994-05-01 00:00:00

abstract：:Radiation myelopathy is a well-known complication of irradiation therapy of neoplasms in the vicinity of the spinal cord. In the case presented myelopathy developed after therapeutic Co 60 irradiation of lingual carcinoma on the background of spinal vasculo-dysraphic malformation. The pathogenetic mechanism of necroti...

journal_title：Clinical neuropathology

authors： Laure-Kamionowska M,Dambska M,Steckiewicz S,Golebiowska D

更新日期：1994-05-01 00:00:00

abstract：:An absence of spongiform change differentiates the pure thalamic degeneration (PTD) from the thalamic form of Creutzfeldt Jakob Disease (CJD). This report describes a case which in addition to the neuropathological changes typical of primary thalamic degeneration showed a single small focus of spongiform change in the...

journal_title：Clinical neuropathology

authors： Kornfeld M,Seelinger DF

更新日期：1994-03-01 00:00:00

abstract：:The clinical history and autopsy findings are reported on a case of infantile Alexander's disease (AD). The patient, a white baby girl, developed seizures at age 4 months accompanied by internal hydrocephalus. She died at age 11 months following a progressive, downhill course of profound psychomotor retardation, recur...

journal_title：Clinical neuropathology

authors： Klein EA,Anzil AP

更新日期：1994-01-01 00:00:00

abstract：:In 37504 autopsies performed during the last 3 decades at the Department of Pathology of Albert Szent-Györgyi Medical University (Szeged, Hungary) gliomas were found in 498 cases. These gliomas were associated with other types of intra- or extracranial tumors in 1.2-3.2% of the cases. Despite the male predominance obs...

journal_title：Clinical neuropathology

authors： Tiszlavicz L

更新日期：1993-07-01 00:00:00

abstract：:A 53-year-old right-handed woman presented with headaches and dizziness. She had been well for ten years following successful cadaveric renal transplantation and was taking prednisolone and azathioprine. Two months later she had more headaches with transient dominant hemisphere disturbances and then suffered a complet...

journal_title：Clinical neuropathology

authors： Heafield MT,Carey M,Williams AC,Cullen M

更新日期：1993-03-01 00:00:00

abstract：:In 37 pituitary adenomas obtained by surgery the immunohistochemical staining for ACTH, GH and prolactin and the tumor size were related to the basal serum hormone levels. 5 adenomas were associated with Cushing syndrome, 9 with acromegaly, 17 with hyperprolactinemia and 6 were preoperatively diagnosed as inactive. A ...

journal_title：Clinical neuropathology

authors： Herzog T,Schlote W,Lorenz R,Jungmann E,Althoff PH

更新日期：1993-03-01 00:00:00

abstract：:Since some monoclonal anti-cytokeratin antibodies also react with glial tumors to a relatively high degree, an immunohistochemical study was performed to examine the reaction of 40 glial tumors and neuroepithelial tumors with glial differentiation to the monoclonal anti-epithelial non-cytokeratin antibodies HEA 125 an...

journal_title：Clinical neuropathology

authors： Gottschalk J,Jautzke G,Zimmer C,Cervós-Navarro J

更新日期：1993-03-01 00:00:00

abstract：:Calbindin D-28k immunoreactivity in the temporal isocortex was examined in seven patients with Alzheimer's disease (AD) and in six controls. In normal brains, calbindin D-28k-immunoreactive cells were bitufted neurons, multipolar cells with ascending dendrites and large double-bouquet cells mainly located in layers II...

journal_title：Clinical neuropathology

authors： Ferrer I,Tuñon T,Soriano E,del Rio A,Iraizoz I,Fonseca M,Guionnet N

更新日期：1993-01-01 00:00:00

abstract：:A 48-year old woman died six days after intake of an unknown amount of trimethyltin (TMT). Early clinical features were tinnitus, lightheadedness, aggression and episodes of unresponsiveness. She gradually developed coma and died of multiorgan failure. The main pathologic findings were confined to the nervous system w...

journal_title：Clinical neuropathology

authors： Kreyberg S,Torvik A,Bjørneboe A,Wiik-Larsen W,Jacobsen D

更新日期：1992-09-01 00:00:00

abstract：:Peripheral neuropathy often occurs in cryoglobulinemia but the pathogenesis of the peripheral nerve involvement is not completely understood, so that the relation between the reported endoneural changes and neuropathy is not clear. In this study we compared the sural nerve biopsies of 6 cryoglobulinemic patients with ...

journal_title：Clinical neuropathology

authors： Tredici G,Petruccioli MG,Cavaletti G,Marmiroli P,Crespi V,Pioltelli P

更新日期：1992-05-01 00:00:00

abstract：:An intracranial mass thought clinically and by computed tomography and angiography to be a meningioma proved to be an inflammatory pseudotumor. The lesion was composed of sheets of mature plasma cells and lymphocytes with germinal center formation. Immunohistochemical studies revealed a polyclonal cell population, sup...

journal_title：Clinical neuropathology

authors： Sitton JE,Harkin JC,Gerber MA

更新日期：1992-01-01 00:00:00

abstract：:Hemangiopericytomas (HP) have a characteristic vascular structure in histologic sections but this has not yet been visualized in three-dimensional form. Parts of typical vascular patterns were separated from paraffin blocks, re-embedded and cut in series. Three-dimensional images were created using the graphic reconst...

journal_title：Clinical neuropathology

authors： von der Stein B,Schröder R

更新日期：1991-11-01 00:00:00

abstract：:A unique pathogenetic process for onion-bulb (Ob) formation is disclosed with disclosed with immunohistochemistry and electron microscopy. Biopsy of a swollen segment of tibial nerve from a 42 year-old white female histologically demonstrated diffuse and angiocentric lymphocytic infiltrate in both endo- and perineuriu...

journal_title：Clinical neuropathology

authors： Chou SM

更新日期：1991-05-01 00:00:00

abstract：:In this study we present a patient with Canavan disease or Van Bogaert and Bertrand type of spongiform leukodystrophy, proven by brain biopsy. We performed morphological studies and biochemical assays on fresh homogenates of the grey and white matter. Quantitative neuromorphological analysis of the cortex showed norma...

journal_title：Clinical neuropathology

authors： de Coo IF,Gabreëls FJ,Renier WO,de Pont JJ,van Haelst UJ,Veerkamp JH,Trijbels JM,Jaspar HH,Renkawek K

更新日期：1991-03-01 00:00:00

abstract：:Primary CNS rhabdoid tumor is an enigmatic and extremely rare malignant tumor of early childhood, probably embryonal, that has often been histopathologically classified together with rhabdoid tumor of kidneys or other organs in infants. Only four previously documented cases of primary CNS malignant rhabdoid tumor (MRT...

journal_title：Clinical neuropathology

authors： Chou SM,Anderson JS

更新日期：1991-01-01 00:00:00

abstract：:A 46-year-old woman suffered a meningococcal meningitis followed by a rapidly progressive lumbosacral pluriradicular syndrome. Myelography showed multiple nodules on the lumbar radices. A biopsy showed tissue with numerous Verocay-like bodies, spindle shaped and lymphocytoid cells which was diagnosed as schwannoma. Th...

journal_title：Clinical neuropathology

authors： Cras P,Ceuterick-de Groote C,Van Vyve M,Vercruyssen A,Martin JJ

更新日期：1990-11-01 00:00:00